Effects generally begin within three hours and last for up to three days. Chlorthalidone only comes as a tablet you take by mouth. Drug Name : Chlorthalidone. Generic Name: . High Blood Pressure. [41] Although chlortalidone is often referred to as a "thiazide-like" diuretic, it is unlike thiazide diuretics in that, in addition to its inhibition of the Na+/Cl− symporter, it also strongly inhibits multiple isoforms of carbonic anhydrase. Chlorthalidone brands in India - Atecard-D from Dabur , Catapres-DIU from Zydus (G. Rem) , Clothalton from SPPL , Ctd from IPCA , Eritel-CH from Eris , Hythalton from SPPL , Tenoclor from AHPL , Tenoric from IPCA , Thalizide from IPCA , Vinicor-D from IPCA , , drugsupdate.com - India's leading online platform for Doctors and health care professionals. * Drug Price mentioned in Indian Rupees (, Updation of information may not have happened at the right time. [1] It is taken by mouth. The 25 mg tablets are light yellow, round, flat faced beveled edged unscored tablets debossed with "Z25" on one side of the tablet and plain on other side. [1][2] In high blood pressure it is a preferred initial treatment. Drug class (es): thiazide diuretics. noun a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks • Syn: ↑Hygroton, ↑Thalidone • Hypernyms: ↑diuretic drug, ↑diuretic,… The information should not be used for either diagnosis or treatment or both for any health related problem or disease. It also helps to relax the blood vessels so that blood can flow more easily. When the treatments were compared chlorthalidone was significantly better than the placebo or magnesium hydroxide (p less than 0.01) [3]. [15] Chlortalidone, like other thiazides, appears effective in people with kidney disease. Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. 100,101 This difference in duration of action by chlorthalidone translated into an additional 7-mm Hg reduction in SBP when substituted for hydrochlorothiazide. Chlorthalidone is used alone or together with other medicines to treat high blood pressure (hypertension). It helps the kidney to get rid of unwanted water and salt from the body into the urine. "Chlorthalidone." They are available as follows: NDC 16714-128-01 in bottle of 100 tablets Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Disclaimer - All information and content on this site are for information and educational purposes only. By blocking sodium ion resorption in the distal convoluted tubule, chlortalidone induces an increase in excretion of sodium ion in urine (natriuresis). [44] Initially, diuretics lower blood pressure by decreasing cardiac output and reducing plasma and extracellular fluid volume. Summary. Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. In Analytical Profiles of Drug Substances, vol. It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor. [1] It is specifically a thiazide-like diuretic. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. Drug information provided by: IBM Micromedex. Regardless of cause, chlortalidone may sometimes improve the severity of edema by reducing intravascular volume and thereby reducing intravascular hydrostatic pressure. [25], Chlortalidone reduces the amount of calcium excreted in urine, reducing the risk of calcium oxalate kidney stones. [5] How it works is not completely clear but is believed to involve increasing the amount of sodium and water lost by the kidneys. [1], Chlortalidone was patented in 1957 and came into medical use in 1960. Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. [24] A secondary analysis of data from the ALLHAT study found that chlortalidone reduced risk of hip and pelvis fracture. Singer, Jeff M., Michael J. O'Hare, Carl R. Rehm, and John E. Zarembo. Meaning of chlorthalidone. Eventually, cardiac output returns to normal, and plasma and extracellular fluid volume return to slightly less than normal, but a reduction in peripheral vascular resistance is maintained, thus resulting in an overall lower blood pressure. Look at other dictionaries: chlorthalidone — /klawr thal i dohn , klohr /, n. Pharm. This reduced delivery of solute to the collecting tubule and medullary collecting duct allows increased water resorption and higher concentration of urine, which leads to reversal of nephrogenic diabetes insipidus by a means that is independent of vasopressin. [13][14][5][6], Trials of chlortalidone for high blood pressure found that lower doses of chlortalidone (e.g., 12.5 mg daily in ALLHAT study) had maximal blood pressure lowering effect and that higher doses did not lower it more. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. This can result in a low blood concentration of potassium and chloride as well as a mild metabolic alkalosis; however, the diuretic effect of chlortalidone is not affected by the acid-base balance of the person being treated. Use in pregnancy: It is better to avoid Chlorthalidone as it crosses the placenta. In high blood pressure it is a preferred initial treatment. 2. Brand Name : Contains: Dosage Form : Manufacturer: Price(Tk.) The reduction in intravascular volume induces an elevation in plasma renin activity and aldosterone secretion, further contributing to the potassium loss associated with thiazide diuretic therapy. Cautions. apical ROMK/Na channels coupled with basolateral Na+/K ATPases). Azilsartan is an angiotensin II receptor antagonist used in the treatment of hypertension, developed by Takeda. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. [50] Sports such as wrestling or boxing categorize athletes according to body weight; taking a diuretic such as chlortalidone may lower body weight, and thereby permit an athlete to compete in a lighter weight class, which would provide an advantage. Chlorthalidone is available under the following different brand names: Hygroton, Thalitone, and Chlorthalid. Definition of chlorthalidone in the Definitions.net dictionary. [20], Chlortalidone may improve edema (swelling) by increasing urinary salt and water excretion, lowering intravascular hydrostatic pressure and thereby lowering transcapillary pressure (see Starling Equation). [CHLOR 2 + (ph)thali(mi)d(ine) a chemical component of the drug + (KET)ONE] * * * … [2] In 2017, it was the 173rd most commonly prescribed medication in the United States, with more than three million prescriptions. Thalitone; Descriptions. chlorothiazide systemic. [47], Chlortalidone is in the sulfamoylbenzamide class. [26] In people who have had multiple episodes of calcium oxalate kidney stones, chlortalidone lowers the risk of having another episode of kidney stones. 1-36. [45], As with other thiazide diuretics, chlortalidone crosses the placenta and is excreted in breast milk. 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